Biomedical Treatment of Autism

Explore recent research addressing biomedical treatment of autism.

The effects of a gluten and casein-free diet in children with autism: a case report.
Hsu CL, Lin CY, Chen CL, Wang CM, Wong MK.
Chang Gung Med J. 2009 Jul-Aug;32(4):459-65.

The authors discuss the case of a boy with autism, and track his substantial improvements when introduced to a gluten and casein-free diet. They conclude that this adjuvant therapy is simple, safe and economical.

Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism.
James SJ, Melnyk S, Fuchs G, Reid T, Jernigan S, Pavliv O, Hubanks A, Gaylor DW.
Am J Clin Nutr. 2009 Jan;89(1):425-30. [Epub 2008 Dec 3.]

The authors seek to determine whether or not treatment with metabolic precursors- methylcobalamin and folinic acid-would improve plasma concentrations of transmethylation/transsulfuration metabolites and glutathione redox status in autistic children. They do observe significant improvements in transmethylation metabolites and glutathione redox status after treatment, suggesting that targeted nutritional intervention with methylcobalamin and folinic acid may be of clinical benefit in some children who have autism.

Gastrointestinal abnormalities in children with autism. [Article in Polish]
Wasilewska J, Jarocka-Cyrta E, Kaczmarski M.
Pol Merkur Lekarski. 2009 Jul;27(157):40-3.

This review of literature on gastrointestinal problems in children with autism spectrum disorders concludes that a beneficial effect of dietary intervention on behavior and cognition of some autistic children indicates a functional relationship between the alimentary tract and the central nervous system.

The ScanBrit randomised, controlled, single-blind study of a gluten- and casein-free dietary intervention for children with autism spectrum disorders.
Whiteley P, Haracopos D, Knivsberg AM, Reichelt KL, Parlar S, Jacobsen J, Seim A, Pedersen L, Schondel M, Shattock P.
Nutr Neurosci. 2010 Apr;13(2):87-100.

Results from this two-staged 24-month study suggest that dietary intervention in the form of gluten- and casein-free diets may positively affect developmental outcome for some children diagnosed with autism spectrum disorder.

Syndrome of allergy, apraxia, and malabsorption: characterization of a neurodevelopmental phenotype that responds to omega 3 and vitamin E supplementation.
Morris CR, Agin MC.
Altern Ther Health Med. 2009 Jul-Aug;15(4):34-43.

Verbal apraxia is a neurologically based motor planning speech disorder of unknown etiology common in autism spectrum disorders. The authors seek to characterize symptoms and metabolic anomalies of a subset of children with verbal apraxia who may respond to nutritional intervention. They ultimately characterize a novel apraxia phenotype that responds to polyunsaturated fatty acids and vitamin E, and conclude that the association of carnitine deficiency, gluten sensitivity/food allergy, and fat malabsorption with the apraxia phenotype suggests that a comprehensive metabolic workup is warranted. The authors also conclude that appropriate screening may identify a subgroup of children with a previously unrecognized syndrome of allergy, apraxia, and malabsorption who are responsive to nutritional intervention, and that controlled trials in apraxia and autism spectrum disorders are warranted.

Bioray / Generation Rescue Liver Life ATEC Study

A joint study between Generation Rescue and Bioray recently took a group of 11 children through a course of Liver Life for 90 days, recording their pre and post ATEC (Treatment Evaluation Checklist) scores.


 

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